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Gene JAK2
Variant R588I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions JAK2 R588I lies within protein kinase domain 1 of the Jak2 protein (UniProt.org). R588I has not been characterized and therefore, its effect on Jak2 protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

JAK2 mutant JAK2 R588I

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Transcript NM_004972.4
gDNA chr9:g.5072613G>T
cDNA c.1763G>T
Protein p.R588I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001322195 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322196 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_004972.3 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322196.1 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322194.1 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322195.1 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322194.2 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322194 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322195.2 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_004972.4 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_004972 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38
NM_001322196.2 chr9:g.5072613G>T c.1763G>T p.R588I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References