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Gene JAK2
Variant V881fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions JAK2 V881fs results in a change in the amino acid sequence of the Jak2 protein beginning at aa 881 of 1132, likely resulting in premature truncation of the functional protein (UniProt.org). V881fs has not been characterized in the scientific literature and therefore, its effect on Jak2 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

JAK2 mutant JAK2 V881fs

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Transcript NM_004972.4
gDNA chr9:g.(5089742_5089743)
cDNA c.(2641_2640)
Protein p.V881fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001322196 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322194 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322195 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322194.2 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322196.2 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_004972.4 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322195.1 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322195.2 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322194.1 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_001322196.1 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_004972.3 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38
NM_004972 chr9:g.(5089742_5089743) c.(2641_2640) p.V881fs RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References