Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | CDK12 |
Variant | G923V |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | CDK12 G923V lies within the protein kinase domain of the Cdk12 protein (PMID: 22512864). G923V has been identified in sequencing studies (PMID: 29906450, PMID: 32997692), but has not been biochemically characterized and therefore, its effect on Cdk12 protein function is unknown (PubMed, Jun 2025). |
Associated Drug Resistance | |
Category Variants Paths |
CDK12 mutant CDK12 G923V |
Transcript | NM_016507.4 |
gDNA | chr17:g.39511630G>T |
cDNA | c.2768G>T |
Protein | p.G923V |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_015083 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
NM_015083.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
NM_015083.4 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
NM_016507 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
NM_016507.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
NM_016507.4 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_005257458 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_005257458.4 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524892 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524892.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524893 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524893.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524893.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524894 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524894.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524894.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524895 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524895.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524895.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524896 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524896.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524897 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524897.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524897.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524898 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524898.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524898.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524899 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524899.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524900 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524900.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524901 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524901.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524902 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524902.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524903 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524903.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524905 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524905.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524906 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524906.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524906.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524907 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524907.2 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_011524907.3 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024744 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024745 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024746 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024747 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024747.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024748 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024748.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024749 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024749.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024750 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024750.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024751 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024751.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024752 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_017024752.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_024450801.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436255.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436256.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436257.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436258.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436259.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436260.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436261.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436265.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436266.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436267.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436268.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436269.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436270.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436272.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436273.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436274.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436275.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436276.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436277.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436278.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436279.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436287.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436288.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436289.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
XM_047436293.1 | chr17:g.39511630G>T | c.2768G>T | p.G923V | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CDK12 mutant | prostate cancer | predicted - sensitive | unspecified PD-1 antibody | Case Reports/Case Series | Actionable | In a clinical study, 50% (2/4) of prostate cancer patients with mutant CDK12 responded to an unspecified checkpoint inhibitor immunotherapy and had a corresponding decrease in prostate specific antigen (PMID: 29906450). | 29906450 |
CKB CORE allows for only a limited number of monthly page views for un-registered users. However, registration is free and allows for unlimited browsing of the CKB CORE content.
You have reached the monthly page view limit. For continued free access to CKB CORE, please register below: