CDK12 K975E
Gene Variant Detail

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Gene CDK12
Variant K975E
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions CDK12 K975E lies within the protein kinase domain of the Cdk12 protein (PMID: 22512864). K975E retains CycK binding and Cdk12 kinase activity in an in vitro assay and induces homologous recombination repair activity in cultured cells, but results in decreased transcriptional activation by Cdk12 in a reporter assay (PMID: 25712099), and therefore, is predicted to lead to a loss of Cdk12 protein function.
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 K975E

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Transcript NM_016507.4
gDNA chr17:g.39517516A>G
cDNA c.2923A>G
Protein p.K975E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005257458 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524901 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024753 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024745 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524900 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024753.2 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024752 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_005257456.4 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024746 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524907 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
NM_016507 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436280.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024749 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524905 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024747 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524898 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524894 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024753.3 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436284.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436262.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524893 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024751 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524897 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
NM_015083 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_005257456 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_005257456.5 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436291.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524899 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436292.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436286.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524896 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524906 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524902 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436283.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024744 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436290.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436263.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436281.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524903 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024748 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436282.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436253.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_017024750 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436285.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_011524895 chr17:g.39517516A>G c.2923A>G p.K975E RefSeq GRCh38/hg38
XM_047436264.1 chr17:g.39517519A>G c.2923A>G p.K975E RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries