CDK12 R858W
Gene Variant Detail

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Gene CDK12
Variant R858W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 R858W lies within the protein kinase domain of the Cdk12 protein (PMID: 22512864). R858W has been identified in the scientific literature (PMID: 30487607, PMID: 39321214, PMID: 35487690), but has not been biochemically characterized and therefore, its effect on Cdk12 protein function is unknown (PubMed, Jun 2025).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 R858W

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Transcript NM_016507.4
gDNA chr17:g.39501402C>T
cDNA c.2572C>T
Protein p.R858W
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.