CDK12 R858W: Gene Variant Detail - Cancer Knowledgebase (CKB)

Gene	CDK12
Variant	R858W
Impact List	missense
Protein Effect	unknown
Gene Variant Descriptions	CDK12 R858W lies within the protein kinase domain of the Cdk12 protein (PMID: 22512864). R858W has been identified in the scientific literature (PMID: 30487607, PMID: 26000489, PMID: 35487690), but has not been biochemically characterized and therefore, its effect on Cdk12 protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths	CDK12 mutant CDK12 R858W

Variant Reference Transcript
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Transcript	NM_016507.4
gDNA	chr17:g.39501402C>T
cDNA	c.2572C>T
Protein	p.R858W
Source Database	RefSeq
Genome Build	GRCh38/hg38

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Showing 1 to 86 of 86 entries

Transcript	gDNA	cDNA	Protein	Source Database	Genome Build
NM_015083	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
NM_015083.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
NM_015083.4	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
NM_016507	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
NM_016507.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
NM_016507.4	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_005257458	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_005257458.4	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524892	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524892.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524893	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524893.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524893.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524894	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524894.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524894.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524895	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524895.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524895.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524896	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524896.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524897	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524897.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524897.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524898	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524898.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524898.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524899	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524899.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524900	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524900.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524901	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524901.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524902	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524902.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524903	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524903.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524905	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524905.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524906	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524906.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524906.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524907	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524907.2	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_011524907.3	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024744	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024745	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024746	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024747	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024747.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024748	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024748.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024749	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024749.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024750	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024750.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024751	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024751.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024752	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_017024752.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_024450801.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436255.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436256.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436257.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436258.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436259.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436260.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436261.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436265.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436266.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436267.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436268.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436269.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436270.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436272.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436273.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436274.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436275.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436276.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436277.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436278.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436279.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436287.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436288.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436289.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38
XM_047436293.1	chr17:g.39501402C>T	c.2572C>T	p.R858W	RefSeq	GRCh38/hg38

Showing 1 to 86 of 86 entries

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
CDK12 R858W	prostate cancer	decreased response	Rucaparib	Preclinical - Cell culture	Actionable	In a preclinical study, expression of CDK12 R858W in CDK12 knockout prostate cancer cell lines demonstrated reduced sensitivity to Rubraca (rucaparib) compared cells with the CDK12 knockout alone in culture (PMID: 39321214).	39321214

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CDK12 R858W - Gene Variant Detail

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