CDK12 R882L
Gene Variant Detail

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Gene CDK12
Variant R882L
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions CDK12 R882L lies within the protein kinase domain of the Cdk12 protein (PMID: 22512864). R882L results in decreased Cdk12-mediated transcriptional activation, downregulation of DNA damage response genes (PMID: 25712099), and decreased kinase activity in cultured cells (PMID: 25712099) and an in vitro assay (PMID: 24554720), but induces proliferation similar to wild-type Cdk12 in one of two tested cell lines in culture (PMID: 29533785), and therefore is predicted to lead to a loss of Cdk12 protein function.
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 R882L

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Transcript NM_016507.4
gDNA chr17:g.39509740G>T
cDNA c.2645G>T
Protein p.R882L
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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