CDK12 Y901C
Gene Variant Detail

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Gene CDK12
Variant Y901C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions CDK12 Y901C lies within the protein kinase domain of the Cdk12 protein (PMID: 22512864). Y901C results in decreased Cdk12 kinase activity, loss of CycK binding, decreased Cdk12-mediated transcriptional activation and down-regulation of DNA damage response genes in cultured cells (PMID: 25712099), and in one of two cell lines, Y901C increased cell proliferation and cell viability as compared to wild-type Cdk12 (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 Y901C

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Transcript NM_016507.4
gDNA chr17:g.39511564A>G
cDNA c.2702A>G
Protein p.Y901C
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.