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Gene CDKN2A
Variant F90fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CDKN2A F90fs results in a change in the amino acid sequence of the Cdkn2a protein beginning at aa 90 of 156, likely resulting in premature truncation of the functional protein (UniProt.org). F90fs has not been characterized, however, due to the effects of other truncation mutations downstream of F90 (PMID: 9053859, PMID: 8668202), is predicted to lead to a loss of Cdkn2a protein function.
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A inact mut CDKN2A F90fs

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Transcript NM_000077.5
gDNA chr9:g.(21971091_21971092)
cDNA c.(268_267)
Protein p.F90fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011517676 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
XM_011517676.2 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
NM_001195132 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
NM_000077 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
XM_011517675 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
NM_000077.4 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
NM_000077.5 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.(21971091_21971092) c.(268_267) p.F90fs RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References