Gene Variant Detail

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Gene APC
Variant N813S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions APC N813S does not lie within any known functional domains of the Apc protein (UniProt.org). N813S results in Axin2 signaling and Tcf/Lef transcriptional activity similar to wild-type Apc in cultured cells (PMID: 15133491), and therefore, is predicted to have no effect on Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC N813S

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Transcript NM_000038.6
gDNA chr5:g.112838032A>G
cDNA c.2438A>G
Protein p.N813S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.6 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001407467.1 chr5:g.112838419A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_000038 chr5:g.112838032A>G c.2438A>G p.N813S RefSeq GRCh38/hg38
NM_001407469.1 chr5:g.112838419A>G c.2438A>G p.N813S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC N813S no effect - predicted