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Gene DNMT3A
Variant L737F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A L737F lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). L737F has been identified in sequencing studies (PMID: 21720365, PMID: 32577167), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A L737F

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Transcript NM_022552.5
gDNA chr2:g.25240415G>A
cDNA c.2209C>T
Protein p.L737F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017003526.1 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
NM_001320893.1 chr2:g.25234351_25234353delCTGinsTTT c.2209_2211delCTGinsTTT p.L737F RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
NM_022552 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_011532664 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_011532664.3 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
NM_001320893 chr2:g.25234351_25234353delCAGinsAAA c.2209_2211delCTGinsTTT p.L737F RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_017003526 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
NM_175629 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38
NM_001320893.1 chr2:g.25234351_25234353delCTGinsTTT c.2209_2211delCTGinsTTT p.L737F RefSeq GRCh38/hg38
XM_005264175 chr2:g.25240415G>A c.2209C>T p.L737F RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References