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Gene DNMT3A
Variant R659H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions DNMT3A R659H lies within the SAM-dependent MTase C5-type domain of the Dnmt3a protein (UniProt.org). R659H has been identified in the scientific literature (PMID: 21519343, PMID: 34815255, PMID: 35456436), but has not been biochemically characterized and therefore, its effect on Dnmt3a protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

DNMT3A mutant DNMT3A R659H

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Transcript NM_022552.5
gDNA chr2:g.25241668C>T
cDNA c.1976G>A
Protein p.R659H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532664.3 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_047443593.1 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
NM_022552.5 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
NM_022552 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_017003526.1 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_017003527.1 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
NM_175629 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_011532664.2 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
NM_022552.4 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_005264177.4 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_011532667.4 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_047443596.1 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_011532667 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_017003526 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_011532667.3 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_005264175 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_047443597.1 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_005264177 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
NM_001375819.1 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_005264175.6 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_017003526.2 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
NM_175629.2 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_005264175.5 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_011532664 chr2:g.25241668C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_017003527 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_017003527.2 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38
XM_047443598.1 chr2:g.25234373C>T c.1976G>A p.R659H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References