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Gene CDKN2A
Variant T77fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CDKN2A T77fs results in a change in the amino acid sequence of the Cdkn2a protein beginning at aa 77 of 156, likely resulting in a premature truncation of the functional protein (UniProt.org). T77fs has not been characterized, however, due to the effects of other truncation mutations downstream of T77 (PMID: 9053859, PMID: 8668202), is predicted to lead to a loss of Cdkn2a protein function.
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A inact mut CDKN2A T77fs

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Transcript NM_000077.5
gDNA chr9:g.(21971130_21971131)
cDNA c.(229_228)
Protein p.T77fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011517676.2 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
XM_011517675 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
NM_001195132 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
NM_000077.5 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
NM_000077.4 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
NM_000077 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
XM_011517676 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.(21971130_21971131) c.(229_228) p.T77fs RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
CDKN2A T77fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor