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Gene TP53
Variant R158L
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 R158L lies within the DNA-binding domain of the Tp53 protein (UniProt.org). R158L results in decreased Tp53 transactivation activity, as demonstrated by loss of p21 expression and decreased activation of Tp53 target genes, but does not interfere with wild-type Tp53 activity in cell culture (PMID: 16861262, PMID: 25584008, PMID: 31067569), and also results in aberrant gene regulation in cultured cells (PMID: 31067569).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 R158L

TP53 mutant TP53 inact mut TP53 R158L

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Transcript NM_000546.6
gDNA chr17:g.7675139C>A
cDNA c.473G>T
Protein p.R158L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126115 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126117.1 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126116.1 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126117 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126116.2 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126116 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_000546 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126117.2 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7673751C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675139C>A c.473G>T p.R158L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 R158L loss of function p53 Activator p53 Gene Therapy