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Gene KIT
Variant W557R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KIT W557R lies within the juxtamembrane domain (exon 11) of the Kit protein (PMID: 15790786). W557R has been identified in the scientific literature (PMID: 37371685, PMID: 37311038, PMID: 26848617) but has not been biochemically characterized and therefore, its effect on Kit protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT exon11 KIT W557R

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Transcript NM_000222.3
gDNA chr4:g.54727437T>A
cDNA c.1669T>A
Protein p.W557R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000222 chr4:g.54727437T>A c.1669T>A p.W557R RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54727437T>A c.1669T>A p.W557R RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54727437T>A c.1669T>A p.W557R RefSeq GRCh38/hg38
XM_017008178 chr4:g.54727437T>A c.1669T>A p.W557R RefSeq GRCh38/hg38
XM_017008178.1 chr4:g.54727437T>A c.1669T>A p.W557R RefSeq GRCh38/hg38
NM_001385285.1 chr4:g.54727437T>A c.1669T>A p.W557R RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05554341 Phase II Nilotinib + Paclitaxel Testing the Use of Nilotinib and Paclitaxel as a Treatment for Patients With Prior Taxane Treatment, A ComboMATCH Treatment Trial Suspended USA 0