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Gene RAD51C
Variant A126T
Impact List missense
Protein Effect no effect
Gene Variant Descriptions RAD51C A126T lies within the Rad51b, Rad51d, and Xrcc3-interaction region of the Rad51c protein (UniProt.org). A126T demonstrates rescue of mitomycin C hypersensitivity and Rad51 foci formation similar to wild-type Rad51c in culture (PMID: 20400964), binds to Rad51b, Rad51d, and Xrcc3 to similar levels of wild-type protein in a yeast assay, and demonstrates homologous recombination activity similar to wild-type Rad51c in cultured cells (PMID: 36099300).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C A126T

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Transcript NM_058216.3
gDNA chr17:g.58695161G>A
cDNA c.376G>A
Protein p.A126T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002876.3 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
NM_002876 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
XM_006722001 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
XM_006722002 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
NM_058216 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695161G>A c.376G>A p.A126T RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References