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Gene RAD51C
Variant G162R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C G162R does not lie within any known functional domains of the Rad51c protein (UniProt.org). G162R results in decreased interaction with Rad51d, Rad51b, and Xrcc3 in a yeast assay (PMID: 36099300), but has not been fully biochemically characterized and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C G162R

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Transcript NM_058216.3
gDNA chr17:g.58696772G>A
cDNA c.484G>A
Protein p.G162R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.4 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
XM_006722002 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
XM_006722001 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
NM_058216 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696772G>A c.484G>A p.G162R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References