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Gene RAD51C
Variant M118I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C M118I lies within a region of the Rad51c protein required for Holliday junction resolution activity and the RAD51B, RAD51D, and XRCC3-interacting region (UniProt.org). M118I has been identified in the scientific literature (PMID: 21798893, PMID: 23333482), but has not been biochemically characterized and therefore, its effect on Rad51c protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C M118I

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Transcript NM_058216.3
gDNA chr17:g.58695139G>C
cDNA c.354G>C
Protein p.M118I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.4 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
NM_058216 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
XM_006722001 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
XM_006722002 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38
NM_002876 chr17:g.58695139G>C c.354G>C p.M118I RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References