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Gene | RAD51C |
Variant | M118I |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RAD51C M118I lies within a region of the Rad51c protein required for Holliday junction resolution activity and the RAD51B, RAD51D, and XRCC3-interacting region (UniProt.org). M118I has been identified in the scientific literature (PMID: 21798893, PMID: 23333482), but has not been biochemically characterized and therefore, its effect on Rad51c protein function is unknown (PubMed, Oct 2024). |
Associated Drug Resistance | |
Category Variants Paths |
RAD51C mutant RAD51C M118I |
Transcript | NM_058216.3 |
gDNA | chr17:g.58695139G>C |
cDNA | c.354G>C |
Protein | p.M118I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_006722001.5 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
XM_006722002.5 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
XM_006722002.4 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
NM_002876 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
XM_047436505.1 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
NM_002876.4 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
NM_058216.3 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
NM_058216 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
NM_002876.3 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
XM_006722001.4 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
XM_006722002 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
NM_058216.2 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
XM_006722001 | chr17:g.58695139G>C | c.354G>C | p.M118I | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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