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Gene RAD51C
Variant P21S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RAD51C P21S lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). P21S binds to Rad51b, Rad51d, and Xrcc3 to similar levels of wild-type protein in a yeast assay (PMID: 36099300) and retains the ability to induce foci formation in culture (PMID: 37253112), and therefore, is predicted to have no effect on Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C P21S

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Transcript NM_058216.3
gDNA chr17:g.58692704C>T
cDNA c.61C>T
Protein p.P21S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.5 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
NM_002876 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
XM_006722002 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
NM_058216 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38
XM_006722001 chr17:g.58692704C>T c.61C>T p.P21S RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References