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Gene RAD51C
Variant P330H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C P330H does not lie within any known functional domains of the Rad51c protein (UniProt.org). P330H retains binding with Rad51b and Xrcc3 and rescues survival in Rad51c-null cells in culture, however, results in decreased binding with Rad51d in a yeast assay and reduced homologous recombination activity in cultured cells (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C P330H

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Transcript NM_058216.3
gDNA chr17:g.58732507C>A
cDNA c.989C>A
Protein p.P330H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58732507C>A c.989C>A p.P330H RefSeq GRCh38/hg38
NM_058216 chr17:g.58732507C>A c.989C>A p.P330H RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58732507C>A c.989C>A p.P330H RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References