RAD51C R249C
Gene Variant Detail

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Gene RAD51C
Variant R249C
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RAD51C R249C does not lie within any known functional domains of the Rad51c protein (UniProt.org). R249C binds to Rad51b, Rad51d, and Xrcc3 at similar levels as wild-type protein in a yeast assay, demonstrates homologous recombination activity similar to wild-type Rad51c in cultured cells, and rescues survival in Rad51c-null cells in culture (PMID: 36099300), and therefore, is predicted to have no effect on Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C R249C

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Transcript NM_058216.3
gDNA chr17:g.58709898C>T
cDNA c.745C>T
Protein p.R249C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017024914 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
XM_017024918 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
NM_058216 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_017024917.1 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
XM_017024916 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_017024915.1 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
XM_017024915 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_006722002 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_017024914.1 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
XM_017024917 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
XM_006722001 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_017024918.2 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_017024916.1 chr17:g.58734187_58734189delCGGinsTGT c.745_747delCGGinsTGT p.R249C RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58709898C>T c.745C>T p.R249C RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References