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Gene CTNNB1
Variant S45del
Impact List deletion
Protein Effect gain of function
Gene Variant Descriptions CTNNB1 S45del results in the deletion of an amino acid at a Gsk3b phosphorylation site of the Ctnnb1 protein at amino acid 45 (PMID: 9065402). S45del confers a gain of function to the Ctnnb1 protein as demonstrated by stabilization and nuclear accumulation of Ctnnb1 (PMID: 9065402, PMID: 21084400).
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 act mut CTNNB1 S45del

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Transcript NM_001098210.2
gDNA chr3:g.41224645_41224647delTCT
cDNA c.133_135delTCT
Protein p.S45delS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047447480.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
NM_001904.3 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_047447482.1 chr3:g.41224666_41224668delCCT c.133_135delCCT p.P45delP RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
NM_001904 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
XM_006712985.2 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
NM_001904.4 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
XM_024453356.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45del RefSeq GRCh38/hg38
NM_001330729.2 chr3:g.41224666_41224668delCCT c.133_135delCCT p.P45delP RefSeq GRCh38/hg38
XM_047447483.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.41224645_41224647delTCT c.133_135delTCT p.S45delS RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
CTNNB1 S45del gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor