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Gene ATR
Variant D2494E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions ATR D2494E lies within the PI3K/PI4K domain of the Atr protein (UniProt.org). D2494E results in a loss of Atr autophosphorylation and Atr-mediated phosphorylation of p53 and c-jun in cell culture (PMID: 10597277).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR D2494E

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Transcript NM_001184.4
gDNA chr3:g.142458979A>C
cDNA c.7482T>G
Protein p.D2494E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001184 chr3:g.142458979A>C c.7482T>G p.D2494E RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142458979A>C c.7482T>G p.D2494E RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142458979A>C c.7482T>G p.D2494E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References