ROS1 S1109L
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene ROS1
Variant S1109L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 S1109L lies within fibronectin type-III domain 5 of the Ros1 protein (UniProt.org). S1109L has been identified in the scientific literature (PMID: 34299796, PMID: 18056464, PMID: 36422072), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 S1109L

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_002944.3
gDNA chr6:g.117362658G>A
cDNA c.3326C>T
Protein p.S1109L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117362658G>A c.3326C>T p.S1109L RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117362658G>A c.3326C>T p.S1109L RefSeq GRCh38/hg38
NM_002944 chr6:g.117362658G>A c.3326C>T p.S1109L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References