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Gene ATR
Variant H2153R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR H2153R lies within the FAT domain of the Atr protein (UniProt.org). H2153R has been identified in sequencing studies (PMID: 24755471), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR H2153R

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Transcript NM_001184.4
gDNA chr3:g.142469431T>C
cDNA c.6458A>G
Protein p.H2153R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001184 chr3:g.142469431T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.142469437T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.142469437T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38
XM_011512924 chr3:g.142469437T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.142469437T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142469431T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.142469437T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142469431T>C c.6458A>G p.H2153R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References