Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene ATR
Variant K771fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ATR K771fs results in a change in the amino acid sequence of the Atr protein beginning at aa 771 of 2644, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the PI3K/PI4K domain and the FATC domain (UniProt.org), K771fs is predicted to lead to a loss of Atr protein function.
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR K771fs

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_001184.4
gDNA chr3:g.(142555907_142555908)
cDNA c.(2311_2310)
Protein p.K771fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047448361.1 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_047448364.1 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
NM_001184.3 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_011512924 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
NM_001184 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
NM_001184.4 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38
XM_011512926 chr3:g.(142555907_142555908) c.(2311_2310) p.K771fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ATR K771fs loss of function - predicted