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Gene ATR
Variant R1025C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR R1025C does not lie within any known functional domains of the Atr protein (UniProt.org). R1025C has been identified in sequencing studies (PMID: 22622578, PMID: 26950094), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR R1025C

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Transcript NM_001184.4
gDNA chr3:g.142549577G>A
cDNA c.3073C>T
Protein p.R1025C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512924.1 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_047448364.1 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
NM_001184 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_011512924 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_011512926 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142549577G>A c.3073C>T p.R1025C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References