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Gene ATR
Variant R1412Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR R1412Q does not lie within any known functional domains of the Atr protein (UniProt.org). R1412Q has been identified in sequencing studies (PMID: 30181556, PMID: 25589618), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR R1412Q

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Transcript NM_001184.4
gDNA chr3:g.142522759C>T
cDNA c.4235G>A
Protein p.R1412Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047448363.1 chr3:g.142522759C>T c.4235G>A p.R1412Q RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142522759C>T c.4235G>A p.R1412Q RefSeq GRCh38/hg38
NM_001184 chr3:g.142522759C>T c.4235G>A p.R1412Q RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142522759C>T c.4235G>A p.R1412Q RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References