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Gene ATR
Variant R1647C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR R1647C lies within the FAT domain of the Atr protein (UniProt.org). R1647C has been identified in sequencing studies (PMID: 32321774), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR R1647C

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Transcript NM_001184.4
gDNA chr3:g.142508023G>A
cDNA c.4939C>T
Protein p.R1647C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001184.3 chr3:g.142508023G>A c.4939C>T p.R1647C RefSeq GRCh38/hg38
NM_001184 chr3:g.142508023G>A c.4939C>T p.R1647C RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142508023G>A c.4939C>T p.R1647C RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142508023G>A c.4939C>T p.R1647C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References