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Gene ATR
Variant R1886*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions ATR R1886* results in a premature truncation of the Atr protein at amino acid 1886 of 2644 (UniProt.org). Due to the loss of the PI3K/PI4K domain and the FATC domain (UniProt.org), R1886* is predicted to lead to a loss of Atr protein function.
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR R1886*

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Transcript NM_001184.4
gDNA chr3:g.142497095G>A
cDNA c.5656C>T
Protein p.R1886*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047448363.1 chr3:g.142497095G>A c.5656C>T p.R1886* RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142497095G>A c.5656C>T p.R1886* RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142497095G>A c.5656C>T p.R1886* RefSeq GRCh38/hg38
NM_001184 chr3:g.142497095G>A c.5656C>T p.R1886* RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References