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Gene | TP53 |
Variant | M237_S241del |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 M237_S241del results in the deletion of five amino acids in the DNA-binding domain of the Tp53 protein (PMID: 22713868). M237_S241del has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Dec 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon7 TP53 M237_S241del |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674241_7674255del15 |
cDNA | c.709_723del15 |
Protein | p.M237_S241del |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |