Gene Variant Detail

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Gene HRAS
Variant K117E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS K117E lies within the GTP binding domain of the Hras protein (UniProt.org). K117E confers a loss of function on Hras protein as indicated by increased GTP-bound Hras, activation of downstream signaling, and transformation of cultured cells (PMID: 12569357).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS K117E

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Transcript NM_005343.4
gDNA chr11:g.533554T>C
cDNA c.349A>G
Protein p.K117E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.4 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_005343 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_176795 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38
NM_001130442 chr11:g.533554T>C c.349A>G p.K117E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References