FGFR2 N550T
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene FGFR2
Variant N550T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 N550T (corresponds to N549T in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N550T results in growth factor-independent growth in a high-throughput cell culture assay (PMID: 41361008), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 N550T

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_022970.4
gDNA chr10:g.121498521T>G
cDNA c.1649A>C
Protein p.N550T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144919 chr10:g.121488064T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144913 chr10:g.121498521T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121488064T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121487992T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_022970 chr10:g.121498521T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498521T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121498521T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121488064T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144914 chr10:g.121487992T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121498521T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498521T>G c.1649A>C p.N550T RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121487992T>G c.1649A>C p.N550T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References