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Gene FGFR2
Variant K641N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 K641N lies within the protein kinase domain of the Fgfr2b protein (UniProt.org). K641N (reported as K642N) results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K641N

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Transcript NM_000141.5
gDNA chr10:g.121488054T>G
cDNA c.1923A>C
Protein p.K641N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141 chr10:g.121488054T>G c.1923A>C p.K641N RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121496532T>G c.1923A>C p.K641N RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121496532T>G c.1923A>C p.K641N RefSeq GRCh38/hg38
XM_006717710 chr10:g.121496532T>G c.1923A>C p.K641N RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488054T>G c.1923A>C p.K641N RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121488054T>G c.1923A>C p.K641N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 K641N Advanced Solid Tumor predicted - sensitive Lirafugratinib Preclinical - Biochemical Actionable In a preclinical study, Lirafugratinib treatment inhibited Fgfr2 phosphorylation in cultured cells expressing FGFR2 K641N (PMID: 37270847). 37270847