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Gene FGFR2
Variant M536I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 M536I (corresponds to M535I in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M536I results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 M536I

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Transcript NM_022970.4
gDNA chr10:g.121498562C>G
cDNA c.1608G>C
Protein p.M536I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006717708.4 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_022970 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121498553C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_006717708 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001320658 chr10:g.121498553C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_017015920 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001144913 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121498553C>G c.1608G>C p.M536I RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FGFR2 M536I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor