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Gene FGFR2
Variant M536I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 M536I (corresponds to M535I in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M536I results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 M536I

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Transcript NM_022970.4
gDNA chr10:g.121498562C>G
cDNA c.1608G>C
Protein p.M536I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006717708.4 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_022970 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_017015920 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_006717708 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121498553C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001320658 chr10:g.121498553C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001144913 chr10:g.121498562C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121498553C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121500833C>G c.1608G>C p.M536I RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 M536I Advanced Solid Tumor decreased response Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 M536I demonstrated a decreased response to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 M536I Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and proliferation in transformed cells expressing FGFR2 M536I (PMID: 23908597). 23908597
FGFR2 M536I Advanced Solid Tumor decreased response PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 M536I demonstrated a decreased response to treatment with PD173074 (PMID: 23908597). 23908597