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FGFR2 V565I - Gene Variant Detail

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Gene FGFR2
Variant V565I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 V565I (corresponds to V564I in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V565I results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 V565I

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Transcript NM_022970.4
gDNA chr10:g.121496705C>T
cDNA c.1693G>A
Protein p.V565I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913 chr10:g.121496705C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
XM_006717711 chr10:g.121488077C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
XM_024447890.2 chr10:g.121488077C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121496705C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496705C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
NM_022970 chr10:g.121496705C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496705C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
XM_024447890.1 chr10:g.121488077C>T c.1693G>A p.V565I RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496705C>T c.1693G>A p.V565I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
FGFR2 V565I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 rearrange FGFR2 N550D FGFR2 N550H FGFR2 N550K FGFR2 N550T FGFR2 V565I FGFR2 V565L
FGFR2 C382R FGFR2 M538I FGFR2 N550D FGFR2 V565I