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Gene ROS1
Variant L2026M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 L2026M lies within the protein kinase domain of the Ros1 protein (UniProt.org). L2026M has been demonstrated to confer resistance to ROS1 inhibitors in the context of a Ros1 fusion (PMID: 25351743, PMID: 32918045), and results in increased colony formation, cell migration, and ERK/AKT signaling in the context of a ROS1 fusion in culture (PMID: 38148635), but has not been individually characterized and therefore, its effect on Ros1 protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 L2026M

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Transcript NM_002944.3
gDNA chr6:g.117317202G>T
cDNA c.6076C>A
Protein p.L2026M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011536050 chr6:g.117317229G>T c.6076C>A p.L2026M RefSeq GRCh38/hg38
NM_002944 chr6:g.117317202G>T c.6076C>A p.L2026M RefSeq GRCh38/hg38
XM_011536050.2 chr6:g.117317229G>T c.6076C>A p.L2026M RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117317202G>T c.6076C>A p.L2026M RefSeq GRCh38/hg38
XM_011536050.3 chr6:g.117317229G>T c.6076C>A p.L2026M RefSeq GRCh38/hg38
NM_002944.3 chr6:g.117317202G>T c.6076C>A p.L2026M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ROS1 L2026M unknown
ROS1 fusion ROS1 L1951R ROS1 L2026M
ROS1 rearrange ROS1 L2026M TP53 P278H