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Gene FGFR2
Variant T730S
Impact List missense
Protein Effect no effect
Gene Variant Descriptions FGFR2 T730S (corresponds to T729S in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). T730S has activity similar to wild-type Fgfr2 as demonstrated by equivalent substrate phosphorylation and the lack of oncogenic cell transformation (PMID: 26048680).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 T730S

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Transcript NM_022970.4
gDNA chr10:g.121485404G>C
cDNA c.2189C>G
Protein p.T730S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121485404G>C c.2189C>G p.T730S RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121485404G>C c.2189C>G p.T730S RefSeq GRCh38/hg38
NM_022970 chr10:g.121485404G>C c.2189C>G p.T730S RefSeq GRCh38/hg38
NM_001144913 chr10:g.121485404G>C c.2189C>G p.T730S RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121485404G>C c.2189C>G p.T730S RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121485404G>C c.2189C>G p.T730S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR2 T730S no effect