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Gene FGFR2
Variant A648T
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions FGFR2 A648T lies within the protein kinase domain of the Fgfr2 protein (PMID: 19147536). A648T confers a loss of function to the Fgfr2 protein demonstrated by decreased proliferation relative to wild-type Fgfr2 in a competition assay and decreased transformation activity (PMID: 34272467), decreaed protein kinase activity, and reduced downstream MAPK signaling pathway activation in cultured cells (PMID: 19147536).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 inact mut FGFR2 A648T

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Transcript NM_000141.5
gDNA chr10:g.121488035C>T
cDNA c.1942G>A
Protein p.A648T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121488035C>T c.1942G>A p.A648T RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488035C>T c.1942G>A p.A648T RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121488095C>T c.1942G>A p.A648T RefSeq GRCh38/hg38
XM_006717710 chr10:g.121488095C>T c.1942G>A p.A648T RefSeq GRCh38/hg38
NM_000141 chr10:g.121488035C>T c.1942G>A p.A648T RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121488095C>T c.1942G>A p.A648T RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References