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Gene FGFR2
Variant G227E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 G227E lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). The functional effect of G227E is conflicting, as it has been reported to impair receptor processing and trafficking to the cell membrane and reduce ligand-dependent cell proliferation in one study (PMID: 19147536), similar cell proliferation and viability levels to wild-type Fgfr2 in two different cell lines in another study (PMID: 29533785), and a growth advantage relative to wild-type Fgfr2 in a competition assay but transformation activity similar to wild-type Fgfr2 in cultured cells (PMID: 34272467), and therefore, its effect on Fgfr2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 G227E

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Transcript NM_000141.5
gDNA chr10:g.121538660C>T
cDNA c.680G>A
Protein p.G227E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144914.1 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_022970 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144913 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144914 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121517455_121517456delGTinsAG c.680_681delGTinsAG p.G227E RefSeq GRCh38/hg38
NM_001144915 chr10:g.121517455_121517456delACinsCT c.680_681delGTinsAG p.G227E RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.121517455_121517456delGTinsAG c.680_681delGTinsAG p.G227E RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121518822C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001320658 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144917 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121517455_121517456delGTinsAG c.680_681delGTinsAG p.G227E RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121517455_121517456delGTinsAG c.680_681delGTinsAG p.G227E RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121518822C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_023029 chr10:g.121517455_121517456delACinsCT c.680_681delGTinsAG p.G227E RefSeq GRCh38/hg38
NM_000141 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121538660C>T c.680G>A p.G227E RefSeq GRCh38/hg38
NM_001144919 chr10:g.121518822C>T c.680G>A p.G227E RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 G227E Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 G227E were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 G227E Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 G227E were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 G227E Advanced Solid Tumor predicted - resistant Dovitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 G227E were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). 34272467
FGFR2 G227E Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 G227E were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 G227E Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 G227E were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 G227E Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 G227E were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 G227E Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 G227E were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467