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Molecular Profile | HRAS Q61L |
Therapy | Buparlisib |
Indication/Tumor Type | lung squamous cell carcinoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS Q61L | lung squamous cell carcinoma | no benefit | Buparlisib | Preclinical - Cell culture | Actionable | In a preclinical study, BKM120 did not inhibit growth of a lung squamous cell carcinoma cell line harboring HRAS Q61L in culture (PMID: 26544513) | 26544513 |
PubMed Id | Reference Title | Details |
---|---|---|
(26544513) | Mutant HRAS as novel target for MEK and mTOR inhibitors. | Full reference... |