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| Molecular Profile | MST1R over exp |
| Therapy | Epirubicin |
| Indication/Tumor Type | urinary bladder cancer |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MST1R over exp | urinary bladder cancer | decreased response | Epirubicin | Preclinical - Cell culture | Actionable | In a preclinical study, MST1R (RON) over expression resulted in decreased sensitivity to Ellence (epirubicin) in bladder cancer cells under hypoxia in culture, resulting in increased cell survival (PMID: 26772202). | 26772202 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26772202) | RON Nuclear Translocation under Hypoxia Potentiates Chemoresistance to DNA Double-Strand Break-Inducing Anticancer Drugs. | Full reference... |