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| Molecular Profile | NRAS G12D |
| Therapy | N-Arachidonoyl Dopamine |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS G12D | Advanced Solid Tumor | sensitive | N-Arachidonoyl Dopamine | Preclinical - Cell culture | Actionable | In a preclinical study, N-Arachidonoyl Dopamine (NADA) disrupted NRAS protein membrane localization and decreased NRAS downstream signaling, and inhibited proliferation and induced cell death in transformed cells expressing NRAS G12D in culture (PMID: 27760835). | 27760835 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27760835) | N-Arachidonoyl Dopamine Inhibits NRAS Neoplastic Transformation by Suppressing Its Plasma Membrane Translocation. | Full reference... |