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| Molecular Profile | AXL positive |
| Therapy | Bemcentinib + Olaparib |
| Indication/Tumor Type | triple-receptor negative breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| AXL positive | triple-receptor negative breast cancer | sensitive | Bemcentinib + Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, an AXL-expressing triple-receptor negative breast cancer cell line demonstrated greater sensitivity to the combination of Bemcentinib (BGB-324) and Lynparza (olaparib) compared to either agent alone in culture, resulting in a highly synergistic effect (PMID: 27671334). | 27671334 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27671334) | AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers. | Full reference... |