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| Molecular Profile | IDH1 R132H |
| Therapy | BPTES |
| Indication/Tumor Type | high grade glioma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H | high grade glioma | sensitive | BPTES | Preclinical - Cell culture | Actionable | In a preclinical study, a glioma cell line expressing IDH1 R132H demonstrated increased sensitivity to growth inhibition by BPTES compared to a cell line expressing wild-type IDH1 in culture (PMID: 21045145). | 21045145 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21045145) | Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. | Full reference... |