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Molecular Profile | IDH1 R132H |
Therapy | BPTES |
Indication/Tumor Type | high grade glioma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | high grade glioma | sensitive | BPTES | Preclinical - Cell culture | Actionable | In a preclinical study, a glioma cell line expressing IDH1 R132H demonstrated increased sensitivity to growth inhibition by BPTES compared to a cell line expressing wild-type IDH1 in culture (PMID: 21045145). | 21045145 |
PubMed Id | Reference Title | Details |
---|---|---|
(21045145) | Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. | Full reference... |