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| Molecular Profile | HRAS Q61L |
| Therapy | NS1 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS Q61L | Advanced Solid Tumor | sensitive | NS1 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing HRAS Q61L demonstrated sensitivity to NS1, resulting in inhibition of Mapk and Akt signaling and cell transformation in culture (PMID: 27820802). | 27820802 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27820802) | Inhibition of RAS function through targeting an allosteric regulatory site. | Full reference... |