Profile Response Detail

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Molecular Profile NRAS G12D
Therapy NS1
Indication/Tumor Type Advanced Solid Tumor
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G12D Advanced Solid Tumor no benefit NS1 Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing NRAS G12D did not respond to treatment with NS1 in culture, resulting in sustained downstream signaling and cell transformation (PMID: 27820802). 27820802
PubMed Id Reference Title Details
(27820802) Inhibition of RAS function through targeting an allosteric regulatory site. Full reference...