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| Molecular Profile | PTEN negative |
| Therapy | Buparlisib |
| Indication/Tumor Type | lung squamous cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN negative | lung squamous cell carcinoma | sensitive | Buparlisib | Phase II | Actionable | In a Phase II trial, one patient with Pten negative squamous NSCLC had a partial response to Buparlisib (BKM120) however, stage 2 of the study was not initiated due to failure of meeting overall stage 1 response endpoints (PMID: 26098748). | 26098748 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26098748) | Safety and Efficacy of Buparlisib (BKM120) in Patients with PI3K Pathway-Activated Non-Small Cell Lung Cancer: Results from the Phase II BASALT-1 Study. | Full reference... |